4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide

Base Information

Chemical Name:4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide
CAS No.:1354818-92-0
Molecular Formula:C₁₈H₁₂ClF₂N₅O₃S₂
Molecular Weight:483.907
Hs Code.:

Synonyms:4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide

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Chemical Property of 4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide

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Technology Process of 4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide

There total 5 articles about 4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354819-13-8
C₂₈H₂₈ClF₂N₅O₆S₂

: 1354818-92-0
4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 50 ℃; for 2h;

Reference yield:

: 259209-20-6
5-fluoro-2-hydroxyphenyl-boronic acid

: 1354818-92-0
4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / toluene / 23 h / 80 °C

1.2: 4 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C

3.1: ammonium chloride; iron / ethanol; water / 4 h / 80 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 50 °C

With hydrogenchloride; iron; potassium carbonate; ammonium chloride; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; toluene;

Reference yield:

: 1354819-29-6
4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol

: 1354818-92-0
4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C

2: ammonium chloride; iron / ethanol; water / 4 h / 80 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 50 °C

With hydrogenchloride; iron; potassium carbonate; ammonium chloride; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide;