1,2,3,4-tetrahydro-2-(2-chloroethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-2-(2-chloroethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione
• CAS No.: 1340544-58-2
• Molecular Formula: C₁₆H₁₆ClN₃O₂
• Molecular Weight: 317.775

Synonyms:1,2,3,4-tetrahydro-2-(2-chloroethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

Chemical Property of 1,2,3,4-tetrahydro-2-(2-chloroethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

Chemical Property:

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Technology Process of 1,2,3,4-tetrahydro-2-(2-chloroethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

There total 2 articles about 1,2,3,4-tetrahydro-2-(2-chloroethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

1,2,3,4-tetrahydro-2-(2-hydroxyethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione (1340544-57-1) → 1,2,3,4-tetrahydro-2-(2-chloroethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione (1340544-58-2)

Guidance literature:

With thionyl chloride; In chloroform; for 2h; Reflux;

DOI:10.1016/j.ejmech.2011.08.006

Reference yield:

2,5-dimethyl-1-phenyl-3,4-pyrroledicarboxylic acid anhydride (158576-66-0) → 1,2,3,4-tetrahydro-2-(2-chloroethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione (1340544-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 7 h / Reflux

2: thionyl chloride / chloroform / 2 h / Reflux

With thionyl chloride; In chloroform; acetonitrile;

DOI:10.1016/j.ejmech.2011.08.006

Reference yield: 16.0%

4-phenyl-1-piperazine (92-54-6) + 1,2,3,4-tetrahydro-2-(2-chloroethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione (1340544-58-2) → 1,2,3,4-tetrahydro-2-[2-(4-phenylpiperazin-1-yl)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione (1340544-42-4)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 16h; Reflux;

DOI:10.1016/j.ejmech.2011.08.006

upstream raw materials:

1,2,3,4-tetrahydro-2-(2-hydroxyethyl)-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

2,5-dimethyl-1-phenyl-3,4-pyrroledicarboxylic acid anhydride

Downstream raw materials:

1,2,3,4-tetrahydro-2-[2-(4-phenylpiperazin-1-yl)ethyl]-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine-1,4-dione

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