diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate

Base Information

Chemical Name:diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate
CAS No.:171360-31-9
Molecular Formula:C₂₂H₂₉F₂O₇P
Molecular Weight:474.439
Hs Code.:

Synonyms:diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate

Suppliers and Price of diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate

There total 5 articles about diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 151075-97-7
3-O-benzyl-1,2-O-isopropylidene-5-O-trifluoromethanesulfonyl-α-D-ribofuranoside

: 171360-39-7
diallyl (α,α-difluoromethyl)phosphonate

: 171360-31-9
diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.166667h;
DOI:10.1021/jo00126a073

Reference yield:

: O-1-((3aR,5S,6R,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(bis(allyloxy)phosphoryl)-2,2-difluoroethyl O-perfluorophenyl carbonothioate

: 171360-31-9
diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate

Guidance literature:: With triethyl borane; tri-n-butyl-tin hydride; In hexane; toluene; at 20 ℃; for 0.25h;
DOI:10.1021/acs.orglett.9b03707

Reference yield:

: 23679-20-1
diallyl phosphite

: 171360-31-9
diallyl (2-((3aR,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,1-difluoroethyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / NaHMDS / tetrahydrofuran / 1.) r.t., 40 min, 2.) 12 h

2: 64 percent / LDA / tetrahydrofuran / 0.17 h / -78 °C

With sodium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00126a073