ethyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Base Information

Chemical Name:ethyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate
CAS No.:1312812-87-5
Molecular Formula:C₃₀H₄₅N₅O₃
Molecular Weight:523.719
Hs Code.:

Synonyms:ethyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Chemical Property of ethyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Technology Process of ethyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

There total 7 articles about ethyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (x)C₂HF₃O₂*C₂₇H₄₁N₅O

: 541-41-3
chloroformic acid ethyl ester

: 1312812-87-5
ethyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 1165799-02-9
tert-butyl [(trans-4-{[({2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate

: 1312812-87-5
ethyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: methanol; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

3: dichloromethane / 3 h / 20 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 1165799-06-3
tert-butyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

: 1312812-87-5
ethyl {[trans-4-({[(2-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 3 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.04.014