Technology Process of (R)-N-(1-(trans-4-(2-(benzyloxy)ethyl)cyclohexyl)but-3-enyl)-2-methylpropane-2-sulfinamide
There total 9 articles about (R)-N-(1-(trans-4-(2-(benzyloxy)ethyl)cyclohexyl)but-3-enyl)-2-methylpropane-2-sulfinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran; dichloromethane;
at 0 ℃;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.58 h / 0 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
2.2: 20 °C
3.1: hydrogenchloride / water; acetonitrile / 2 h / 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere
4.2: -40 - 20 °C
5.1: diborane-dimethylsulfide complex / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
5.2: 2.5 h / 0 - 20 °C
6.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere
6.2: 0.58 h / -78 - 20 °C
7.1: titanium(IV) tetraethanolate / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere
8.1: tetrahydrofuran; dichloromethane / 1 h / 0 °C / Inert atmosphere
With
hydrogenchloride; titanium(IV) tetraethanolate; lithium aluminium tetrahydride; oxalyl dichloride; diborane-dimethylsulfide complex; potassium tert-butylate; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile; mineral oil;
4.1: |Wittig Olefination / 4.2: |Wittig Olefination / 6.1: |Swern Oxidation / 6.2: |Swern Oxidation;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 1810.07 Torr
2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.58 h / 0 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
3.2: 20 °C
4.1: hydrogenchloride / water; acetonitrile / 2 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere
5.2: -40 - 20 °C
6.1: diborane-dimethylsulfide complex / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
6.2: 2.5 h / 0 - 20 °C
7.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere
7.2: 0.58 h / -78 - 20 °C
8.1: titanium(IV) tetraethanolate / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere
9.1: tetrahydrofuran; dichloromethane / 1 h / 0 °C / Inert atmosphere
With
hydrogenchloride; titanium(IV) tetraethanolate; lithium aluminium tetrahydride; oxalyl dichloride; diborane-dimethylsulfide complex; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile; mineral oil;
5.1: |Wittig Olefination / 5.2: |Wittig Olefination / 7.1: |Swern Oxidation / 7.2: |Swern Oxidation;
