N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide

Base Information

Chemical Name:N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide
CAS No.:373622-96-9
Molecular Formula:C₁₈H₂₀N₂O₇
Molecular Weight:376.366
Hs Code.:

Synonyms:N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide

Suppliers and Price of N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide

Chemical Property:

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Technology Process of N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide

There total 2 articles about N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: bis(triphenylphosphine)palladium(II) dichloride

aqueous KHCO₃: aqueous KHCO₃

: 57234-28-3
1-methoxy-3-(methoxymethoxy)benzene

: 373622-95-8
2-bromo-N-methoxy-N-methyl-5-nitrobenzamide

: 373622-96-9
N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; chloroform;

Reference yield:

: 57234-28-3
1-methoxy-3-(methoxymethoxy)benzene

: 373622-95-8
2-bromo-N-methoxy-N-methyl-5-nitrobenzamide

: 373622-96-9
N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide

Guidance literature:: 1-methoxy-3-(methoxymethoxy)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -30 - 20 ℃;

With zinc(II) chloride; In tetrahydrofuran; hexane; at 0 - 20 ℃;

2-bromo-N-methoxy-N-methyl-5-nitrobenzamide; With bis-triphenylphosphine-palladium(II) chloride; at 65 ℃;
DOI:10.1016/j.bmcl.2004.02.048

Reference yield:

: 373622-96-9
N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide

: 373622-99-2
4-Amino-2(alpha-hydroxybenzyl)-2'-methoxymethoxy-6'-methoxy-biphenyl

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / 1 h / 3040 Torr

2: 85 percent / diethyl ether; cyclohexane / 1 h / -5 °C

3: 80 percent / NaBH₄ / ethanol / 1 h / 65 °C

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol; cyclohexane;
DOI:10.1016/j.bmcl.2004.02.048