1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide

Base Information

• Chemical Name: 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide
• CAS No.: 1571067-43-0
• Molecular Formula: C₄₁H₄₆N₄O₆S₂Si
• Molecular Weight: 783.057
• Mol file: 1571067-43-0.mol

Synonyms:1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide

Chemical Property of 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide

There total 1 articles about 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile (1571067-40-7) → 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide (1571067-43-0)

Guidance literature:

With hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In 1,4-dioxane; water; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo4027148

Reference yield:

1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide (1571067-43-0) + Tosyl isocyanate (4083-64-1) → C49H53N5O9S3Si (1571067-44-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo4027148

Reference yield:

1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide (1571067-43-0) → N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide (1571074-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2: dichloromethane / 2 h / 50 °C / Inert atmosphere

In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo4027148

upstream raw materials:

1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile

Downstream raw materials:

C₄₉H₅₃N₅O₉S₃Si

N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide