methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate

Base Information

Chemical Name:methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate
CAS No.:1459732-44-5
Molecular Formula:C₂₄H₁₆F₂N₄O₂
Molecular Weight:430.413
Hs Code.:

Synonyms:methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate

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Chemical Property of methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate

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Technology Process of methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate

There total 10 articles about methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1190989-09-3
3,5-difluoro-4-(methoxycarbonyl)phenylboronic acid

: 1350426-10-6
6-((5-chloro-3H-imidazo[4,5-b]pyridin-3-yl)methyl)quinoline

: 1459732-44-5
methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; In 1,4-dioxane; at 100 ℃; for 0.75h; Microwave irradiation;

Reference yield: 77.0%

: 1459732-44-5
methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.75h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 5382-43-4
quinoline-6-carboxamide

: 1459732-44-5
methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic anhydride; triethylamine / chloroform / 1.5 h / 10 °C

2: ammonia; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

3: sodium carbonate / water; ethanol / 12 h / 0 - 20 °C

4: tin(IV) chloride; hydrogenchloride / 2 h / 20 °C

5: 12 h / 100 °C

6: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.75 h / 100 °C / Microwave irradiation

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; potassium acetate; tin(IV) chloride; sodium carbonate; triethylamine; trifluoroacetic anhydride; In 1,4-dioxane; methanol; ethanol; chloroform; water;