3-Chloro-5-phenoxy-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Base Information

• Chemical Name: 3-Chloro-5-phenoxy-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide
• CAS No.: 660394-88-7
• Molecular Formula: C₂₃H₁₇ClN₂O₄S
• Molecular Weight: 452.918

Synonyms:3-Chloro-5-phenoxy-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property of 3-Chloro-5-phenoxy-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property:

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Technology Process of 3-Chloro-5-phenoxy-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

There total 2 articles about 3-Chloro-5-phenoxy-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

vanillin (121-33-5,8014-42-4) + 2-hydrazinocarbonyl-3-chloro-5-phenoxy-benzo(b)thiophene (660394-82-1) → 3-Chloro-5-phenoxy-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide (660394-88-7)

Guidance literature:

In 1,4-dioxane; for 5h; Heating;

Reference yield:

3-chloro-5-phenoxybenzothiophene-2-carbonyl chloride (122024-72-0) → 3-Chloro-5-phenoxy-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide (660394-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / hydrazine hydrate / dioxane / 6 h / Heating

2: 59 percent / dioxane / 5 h / Heating

With hydrazine hydrate; In 1,4-dioxane;

Reference yield: 72.0%

chloroacetyl chloride (79-04-9) + 3-Chloro-5-phenoxy-benzo[b]thiophene-2-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide (660394-88-7) → 4-(4'-hydroxy-3'-methoxyphenyl)-3-chloro-1-(3'-chloro-5'-phenoxy-2'-benzo[b]thiophenecarbonylamino)-2-azetidinone

Guidance literature:

With triethylamine; In 1,4-dioxane; at 0 - 20 ℃; for 60h;

upstream raw materials:

vanillin

2-hydrazinocarbonyl-3-chloro-5-phenoxy-benzo(b)thiophene

3-chloro-5-phenoxybenzothiophene-2-carbonyl chloride

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