{N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester

Base Information

Chemical Name:{N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester
CAS No.:367955-07-5
Molecular Formula:C₂₀H₂₈F₂N₂O₅
Molecular Weight:414.45
Hs Code.:

Synonyms:{N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester

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Chemical Property of {N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester

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Technology Process of {N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester

There total 6 articles about {N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 72648-80-7
ethyl 2-[2-(tert-butoxycarbonylamino)ethyl-[3-[[4-(4,5-difluoro-2-methylsulfanyl-phenyl)phenoxy]methyl]benzoyl]amino]acetate

: 367955-02-0
(2,4-Difluoro-5-methylphenyl)acetic acid

: 367955-07-5
{N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester

Guidance literature:: With triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1039/b103170h

Reference yield:

: 159277-47-1
1-bromo-2,4-difluoro-5-methylbenzene

: 367955-07-5
{N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 50 percent / dimethylformamide / 3 h / 160 °C

2: 100 percent / aq. H₂SO₄ / 1 h / Heating

3: Et₃N / tetrahydrofuran / 0.25 h / -15 °C

4: 710 mg / tetrahydrofuran; diethyl ether / 3 h / 20 °C

5: 60 percent / Et₃N / PhCOOAg / 3 h / -25 - 20 °C

6: 58 percent / aq. LiOH / tetrahydrofuran / 20 °C

7: 52 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; DCC; Et₃N / dimethylformamide / 0 - 20 °C

With lithium hydroxide; sulfuric acid; triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; silver benzoate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 5: Arndt-Eistert rearrangement;
DOI:10.1039/b103170h

Reference yield:

: 329314-68-3
2,4-difluoro-5-methylbenzonitrile

: 367955-07-5
{N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / aq. H₂SO₄ / 1 h / Heating

2: Et₃N / tetrahydrofuran / 0.25 h / -15 °C

3: 710 mg / tetrahydrofuran; diethyl ether / 3 h / 20 °C

4: 60 percent / Et₃N / PhCOOAg / 3 h / -25 - 20 °C

5: 58 percent / aq. LiOH / tetrahydrofuran / 20 °C

6: 52 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; DCC; Et₃N / dimethylformamide / 0 - 20 °C

With lithium hydroxide; sulfuric acid; triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; silver benzoate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 4: Arndt-Eistert rearrangement;
DOI:10.1039/b103170h