Technology Process of (2,4-Difluoro-5-methylphenyl)acetic acid
There total 8 articles about (2,4-Difluoro-5-methylphenyl)acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1039/b103170h
- Guidance literature:
-
1-(bromomethyl)-2,4-difluoro-5-methylbenzene;
With
magnesium;
In
diethyl ether;
for 2.66667h;
Reflux;
carbon dioxide;
In
diethyl ether;
at -10 - 0 ℃;
for 1h;
With
hydrogenchloride;
In
diethyl ether; water;
DOI:10.1002/hlca.201100243
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 50 percent / dimethylformamide / 3 h / 160 °C
2: 100 percent / aq. H2SO4 / 1 h / Heating
3: Et3N / tetrahydrofuran / 0.25 h / -15 °C
4: 710 mg / tetrahydrofuran; diethyl ether / 3 h / 20 °C
5: 60 percent / Et3N / PhCOOAg / 3 h / -25 - 20 °C
6: 58 percent / aq. LiOH / tetrahydrofuran / 20 °C
With
lithium hydroxide; sulfuric acid; triethylamine;
silver benzoate;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
5: Arndt-Eistert rearrangement;
DOI:10.1039/b103170h
