367955-02-0

Basic information

• Product Name: (2,4-Difluoro-5-methylphenyl)acetic acid
• Synonyms: (2,4-Difluoro-5-methylphenyl)acetic acid
• CAS NO: 367955-02-0
• Molecular Weight: 186.158
• Mol File: 367955-02-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2,4-Difluoro-5-methylphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-Difluoro-5-methylphenyl)acetic acid(367955-02-0)
• EPA Substance Registry System: (2,4-Difluoro-5-methylphenyl)acetic acid(367955-02-0)

Safety Data

• Hazardous Substances Data: 367955-02-0(Hazardous Substances Data)

Upstream product

• 452-76-6 2,4-difluorotoluene 
• 124-38-9 carbon dioxide 
• 315204-37-6 1-(bromomethyl)-2,4-difluoro-5-methylbenzene 
• 367954-99-2 2,4-Difluoro-5-methylbenzoic acid 
• 367955-00-8 2-Diazo-1-(2,4-difluoro-5-methylphenyl)ethanone 
• 329314-68-3 2,4-difluoro-5-methylbenzonitrile 
• 159277-47-1 1-bromo-2,4-difluoro-5-methylbenzene 
• 367955-01-9 (2,4-difluoro-5-methyl-phenyl)-acetic acid methyl ester 

Downstream Products

• 1352089-56-5 Boc-Aeg(C[z])-Aeg(F)-Aeg(G[z])-OBn 
• 367955-07-5 {N-[2-(tert-Butoxycarbonylamino)ethyl]-N-[2-(2,4-difluoro-5-methylphenyl)acetyl]amino}acetic acid ethyl ester 

Relevant articles and documents

Improved Large-Scale Liquid-Phase Synthesis and High-Temperature NMR Characterization of Short (F-)PNAs

We report on a large-scale synthesis of F-PNA trimer 10 and PNA trimer 11. The key improvement is the facile two-step synthesis of (2,4-difluoro-5- methylphenyl)acetic acid (2). Water solubility of the corresponding F-PNA oligomer 10 was achieved by synthesizing solubility enhancer 5a, which is twofold positively charged and only consists of inherent structural elements of PNA. Protected and unpaired PNA n-mers exist in a mixture of 2n conformers undergoing slow exchange and leading to complicated NMR spectra. Structure analysis was improved by recording 1H- and 13C-NMR spectra at elevated temperatures above the coalescence point. Fully protected backbone derivatives show sharp resonances where expected, and spectra of protected PNAs are remarkably simplified, thereby allowing an interpretation for the first time. Both trimers 10 and 11 are considered as building blocks for a self-replicating system based on PNA. Copyright