5-((R)-2-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)butyl)-2-n-butoxybenzaldehyde

Base Information

Chemical Name:5-((R)-2-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)butyl)-2-n-butoxybenzaldehyde
CAS No.:1259391-13-3
Molecular Formula:C₃₀H₃₁NO₅
Molecular Weight:485.58
Hs Code.:

Synonyms:5-((R)-2-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)butyl)-2-n-butoxybenzaldehyde

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Chemical Property of 5-((R)-2-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)butyl)-2-n-butoxybenzaldehyde

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Technology Process of 5-((R)-2-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)butyl)-2-n-butoxybenzaldehyde

There total 8 articles about 5-((R)-2-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)butyl)-2-n-butoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: C₃₀H₃₃NO₅

: 1259391-13-3
5-((R)-2-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)butyl)-2-n-butoxybenzaldehyde

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃;
DOI:10.1021/jm101233f

Reference yield:

: 1259391-06-4
benzyl 5-bromomethyl-2-propoxybenzoate

: 1259391-13-3
5-((R)-2-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)butyl)-2-n-butoxybenzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

1.2: -50 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 735.07 Torr

3.1: borane-THF / tetrahydrofuran / 20 °C

4.1: manganese(IV) oxide / dichloromethane / 20 °C

With manganese(IV) oxide; borane-THF; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethyl acetate; 1.1: Evan's asymmetric alkylation / 1.2: Evan's asymmetric alkylation;
DOI:10.1021/jm101233f

Reference yield:

: 1259391-11-1
benzyl 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

: 1259391-13-3
5-((R)-2-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)butyl)-2-n-butoxybenzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 735.07 Torr

2: borane-THF / tetrahydrofuran / 20 °C

3: manganese(IV) oxide / dichloromethane / 20 °C

With manganese(IV) oxide; borane-THF; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm101233f