Technology Process of 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid
There total 6 articles about 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
at 20 ℃;
for 3h;
under 735.074 Torr;
DOI:10.1021/jm101233f
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere
1.2: -50 - 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 735.07 Torr
With
palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane;
In
tetrahydrofuran; ethyl acetate;
1.1: Evan's asymmetric alkylation / 1.2: Evan's asymmetric alkylation;
DOI:10.1021/jm101233f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C
3.1: sodium tetrahydroborate / ethanol / 0 - 20 °C
4.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C
5.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere
5.2: -50 - 20 °C / Inert atmosphere
6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 735.07 Torr
With
sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; phosphorus tribromide; potassium carbonate; potassium hydrogencarbonate;
In
tetrahydrofuran; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
5.1: Evan's asymmetric alkylation / 5.2: Evan's asymmetric alkylation;
DOI:10.1021/jm101233f
