5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

Base Information

Chemical Name:5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid
CAS No.:1259391-12-2
Molecular Formula:C₃₀H₃₁NO₆
Molecular Weight:501.579
Hs Code.:

Synonyms:5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

Suppliers and Price of 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

There total 6 articles about 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259391-11-1
benzyl 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

: 1259391-12-2
5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 3h; under 735.074 Torr;
DOI:10.1021/jm101233f

Reference yield:

: 1259391-06-4
benzyl 5-bromomethyl-2-propoxybenzoate

: 1259391-12-2
5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

1.2: -50 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 735.07 Torr

With palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; 1.1: Evan's asymmetric alkylation / 1.2: Evan's asymmetric alkylation;
DOI:10.1021/jm101233f

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1259391-12-2
5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

3.1: sodium tetrahydroborate / ethanol / 0 - 20 °C

4.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

5.2: -50 - 20 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 735.07 Torr

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; phosphorus tribromide; potassium carbonate; potassium hydrogencarbonate; In tetrahydrofuran; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide; 5.1: Evan's asymmetric alkylation / 5.2: Evan's asymmetric alkylation;
DOI:10.1021/jm101233f