Technology Process of benzyl 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate
There total 5 articles about benzyl 5-((S)-2-benzyl-3-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-4-benzyl-3-(3-phenyl-propionyl)-oxazolidin-2-one;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -50 - -15 ℃;
Inert atmosphere;
benzyl 5-bromomethyl-2-propoxybenzoate;
In
tetrahydrofuran;
at -50 - 20 ℃;
Inert atmosphere;
DOI:10.1021/jm101233f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C
3.1: sodium tetrahydroborate / ethanol / 0 - 20 °C
4.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C
5.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere
5.2: -50 - 20 °C / Inert atmosphere
With
sodium tetrahydroborate; sodium hexamethyldisilazane; phosphorus tribromide; potassium carbonate; potassium hydrogencarbonate;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
5.1: Evan's asymmetric alkylation / 5.2: Evan's asymmetric alkylation;
DOI:10.1021/jm101233f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C
2.1: sodium tetrahydroborate / ethanol / 0 - 20 °C
3.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C
4.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere
4.2: -50 - 20 °C / Inert atmosphere
With
sodium tetrahydroborate; sodium hexamethyldisilazane; phosphorus tribromide; potassium carbonate;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
4.1: Evan's asymmetric alkylation / 4.2: Evan's asymmetric alkylation;
DOI:10.1021/jm101233f
