(S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER

Base Information

Chemical Name:(S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER
CAS No.:103733-31-9
Molecular Formula:C₁₆H₂₃NO₄
Molecular Weight:293.363
Hs Code.:2933499090
Mol file:103733-31-9.mol

Synonyms:TERT-BUTYL 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;(S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER

Suppliers and Price of (S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylicAcid1,1-DimethylethylEster
500 mg
$ 2200.00

American Custom Chemicals Corporation
(S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER 95.00%
500MG
$ 1963.50

American Custom Chemicals Corporation
(S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER 95.00%
50MG
$ 750.75

Total 6 raw suppliers

Chemical Property of (S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER

Chemical Property:

Vapor Pressure:1.29E-06mmHg at 25°C
Refractive Index:1.509
Boiling Point:400.2°C at 760 mmHg
PKA:7.00±0.40(Predicted)
Flash Point:195.8°C
PSA：56.79000
Density:1.096g/cm³
LogP:2.38860
Storage Temp.:-20°C Freezer
Solubility.:Chloroform, Dichloromethane, Dimethyl Sulfoxide, Ethyl Acetate, Methanol

Purity/Quality:

98%min ^*data from raw suppliers

(S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylicAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Used in the preparation of Moexipril (M485350) and it’s impurities.

Technology Process of (S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER

There total 3 articles about (S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 82586-62-7
(S)‐6,7‐dimethoxy‐1,2,3,4-tetrahydroisoquinoline‐3‐carboxylate hydrochloride

: 115-11-7,15220-85-6
isobutene

: 103733-66-0,103733-31-9
tert-butyl (S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Guidance literature:: With sulfuric acid; In 1,4-dioxane; at 20 ℃; for 18h; Sealed tube;
DOI:10.1002/chem.201904400

Reference yield:

: 32161-30-1
(S)-3,4-dimethoxyphenylalanine

: 103733-66-0,103733-31-9
tert-butyl (S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 3 h / 90 °C / Sealed tube

2: sulfuric acid / 1,4-dioxane / 18 h / 20 °C / Sealed tube

With hydrogenchloride; sulfuric acid; In 1,4-dioxane; water;
DOI:10.1002/chem.201904400