4-(8-cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester

Base Information

• Chemical Name: 4-(8-cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester
• CAS No.: 345964-37-6
• Molecular Formula: C₂₇H₃₀O₃
• Molecular Weight: 402.533

Synonyms:4-(8-cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester

Chemical Property of 4-(8-cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester

Chemical Property:

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Technology Process of 4-(8-cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester

There total 3 articles about 4-(8-cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

8-Cyclopropyl-6-ethynyl-2,2,4,4-tetramethyl chroman (345964-36-5) + 4-iodobenzoic acid ethyl ester (51934-41-9) → 4-(8-cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester (345964-37-6)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran;

Reference yield: 89.0%

4-(8-Cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid (345963-30-6) + 4-iodobenzoic acid ethyl ester (51934-41-9) → 4-(8-cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester (345964-37-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; triethylamine;

Reference yield:

copper(l) iodide (7681-65-4) + 8-Cyclopropyl-6-ethynyl-2,2,4,4-tetramethyl chroman (345964-36-5) + 4-iodobenzoic acid ethyl ester (51934-41-9) → 4-(8-cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester (345964-37-6)

Guidance literature:

With triethylamine; dichlorobis(triphenylphosphine)palladium[II]; In tetrahydrofuran; hexane;

upstream raw materials:

8-Cyclopropyl-6-ethynyl-2,2,4,4-tetramethyl chroman

4-iodobenzoic acid ethyl ester

4-(8-Cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid

copper(l) iodide

Downstream raw materials:

4-(8-Cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid

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