1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine

Base Information

• Chemical Name: 1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine
• CAS No.: 878167-10-3
• Molecular Formula: C₁₉H₁₉ClINO
• Molecular Weight: 439.723
• Mol file: 878167-10-3.mol

Synonyms:1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine

Chemical Property of 1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine

There total 1 articles about 1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-chloro-2-iodo phenol (71643-66-8) + 1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinemethanol (158984-76-0) → 1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine (878167-10-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃;

Reference yield:

1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine (878167-10-3) → 2,3-dihydro-1'-benzyl-5-chlorospiro(benzofuran-3,4'-piperidine) (878167-11-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 8h; Heating / reflux;

Reference yield:

1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine (878167-10-3) → 2,3-dihydro-1'-benzyl-5-chlorospiro(benzofuran-3,4'-piperidine) hydrochloride

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 8h; Heating / reflux;

upstream raw materials:

4-chloro-2-iodo phenol

1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinemethanol

Downstream raw materials:

2,3-dihydro-1'-benzyl-5-chlorospiro(benzofuran-3,4'-piperidine)