(R)-2-[5-cyano-4-3-(2H-1,2,3-triazol-2-yl)phenylamino-6-methoxypyrimidin-2-ylamino]-3-methylbutanamide

Base Information

Chemical Name:(R)-2-[5-cyano-4-3-(2H-1,2,3-triazol-2-yl)phenylamino-6-methoxypyrimidin-2-ylamino]-3-methylbutanamide
CAS No.:1374157-01-3
Molecular Formula:C₁₉H₂₁N₉O₂
Molecular Weight:407.435
Hs Code.:

Synonyms:(R)-2-[5-cyano-4-3-(2H-1,2,3-triazol-2-yl)phenylamino-6-methoxypyrimidin-2-ylamino]-3-methylbutanamide

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Chemical Property of (R)-2-[5-cyano-4-3-(2H-1,2,3-triazol-2-yl)phenylamino-6-methoxypyrimidin-2-ylamino]-3-methylbutanamide

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Technology Process of (R)-2-[5-cyano-4-3-(2H-1,2,3-triazol-2-yl)phenylamino-6-methoxypyrimidin-2-ylamino]-3-methylbutanamide

There total 6 articles about (R)-2-[5-cyano-4-3-(2H-1,2,3-triazol-2-yl)phenylamino-6-methoxypyrimidin-2-ylamino]-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: C₁₉H₂₁N₉O₂S

: 1374157-01-3
(R)-2-[5-cyano-4-3-(2H-1,2,3-triazol-2-yl)phenylamino-6-methoxypyrimidin-2-ylamino]-3-methylbutanamide

Guidance literature:: With potassium carbonate; at 20 ℃; for 0.0833333h;

Reference yield:

: 1374156-84-9
4-(3-(2H-1,2,3-triazol-3-yl)phenylamino)-2-(ethylthio)-6-(methylthio)pyrimidine-5-carbonitrile

: 1374157-01-3
(R)-2-[5-cyano-4-3-(2H-1,2,3-triazol-2-yl)phenylamino-6-methoxypyrimidin-2-ylamino]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0.5 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C

3: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0.17 h / 20 °C

4: potassium carbonate / 0.08 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; acetonitrile;

Reference yield:

: 626248-56-4
3-(2H-1,2,3-triazol-2-yl)aniline

: 1374157-01-3
(R)-2-[5-cyano-4-3-(2H-1,2,3-triazol-2-yl)phenylamino-6-methoxypyrimidin-2-ylamino]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 5 h / 65 °C

2: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0.5 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C

4: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0.17 h / 20 °C

5: potassium carbonate / 0.08 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;