C₂₆H₂₀N₂O₄

Base Information

• Chemical Name: C₂₆H₂₀N₂O₄
• CAS No.: 1208331-23-0
• Molecular Formula: C₂₆H₂₀N₂O₄
• Molecular Weight: 424.456
• Mol file: 1208331-23-0.mol

Synonyms:C₂₆H₂₀N₂O₄

Chemical Property of C₂₆H₂₀N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₀N₂O₄

There total 9 articles about C₂₆H₂₀N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-methyl-benzoic acid methyl ester (99548-55-7) → C26H20N2O4 (1208331-23-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 8 h / Reflux

2.1: water; sodium hydroxide / ethanol / 12 h / 20 °C

3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 14 h / 70 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: water; dimethyl sulfoxide / 2.5 h / 150 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C / Inert atmosphere

7.1: ozone / dichloromethane / 0.67 h / -78 °C

7.2: -78 - 20 °C

8.1: acetic acid / ethanol / 2 h / 60 °C

With thionyl chloride; water; ozone; acetic acid; N,N-dimethyl-formamide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

5-Aminosalicylic Acid (89-57-6) + 4-(2-(4-methoxyphenyl)-4-oxobutanoyl)-3-methylbenzonitrile (1208331-37-6) → C26H20N2O4 (1208331-23-0)

Guidance literature:

With acetic acid; In ethanol; at 60 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

ethyl 3-(4-cyano-2-methylphenyl)-2-(4-methoxyphenyl)-3-oxopropanoate (1208331-31-0) → C26H20N2O4 (1208331-23-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: water; dimethyl sulfoxide / 2.5 h / 150 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: ozone / dichloromethane / 0.67 h / -78 °C

3.2: -78 - 20 °C

4.1: acetic acid / ethanol / 2 h / 60 °C

With ozone; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2011.04.086

upstream raw materials:

ethyl 3-(4-cyano-2-methylphenyl)-2-(4-methoxyphenyl)-3-oxopropanoate

4-(2-(4-methoxyphenyl)acetyl)-3-methylbenzonitrile

4-(2-(4-methoxyphenyl)pent-4-enoyl)-3-methylbenzonitrile

5-Aminosalicylic Acid

Downstream raw materials:

5-(2-(4-carbamoyl-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)-2-hydroxybenzoic acid