<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-hydroxyphenyl)-4-methyl-2-pyrrolidinone hydrobromide

Base Information

Chemical Name:<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-hydroxyphenyl)-4-methyl-2-pyrrolidinone hydrobromide
CAS No.:131490-77-2
Molecular Formula:BrH*C₁₁H₁₄N₂O₂
Molecular Weight:287.156
Hs Code.:

Synonyms:<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-hydroxyphenyl)-4-methyl-2-pyrrolidinone hydrobromide

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Chemical Property of <3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-hydroxyphenyl)-4-methyl-2-pyrrolidinone hydrobromide

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Technology Process of <3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-hydroxyphenyl)-4-methyl-2-pyrrolidinone hydrobromide

There total 3 articles about <3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-hydroxyphenyl)-4-methyl-2-pyrrolidinone hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 131490-73-8
<2(S,R),3(S,R),4(S,R)>-2-amino-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide

: 131490-77-2
<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-hydroxyphenyl)-4-methyl-2-pyrrolidinone hydrobromide

Guidance literature:: In hydrogen bromide; acetic acid; for 20h; Heating;
DOI:10.1021/jo00005a042

Reference yield:

: 88072-83-7
<5(S,R),4(S,R)>-5-(4-methoxyphenyl)-4-methyl-N-tert-butylisoxazolinecarboxamide

: 131490-77-2
<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-hydroxyphenyl)-4-methyl-2-pyrrolidinone hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 1.) -78 deg C, 1 h 2.) 4 deg C, 18 h

2: 100 percent / acetic acid; HBr / 20 h / Heating

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; hydrogen bromide; acetic acid; toluene;
DOI:10.1021/jo00005a042

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 131490-77-2
<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-hydroxyphenyl)-4-methyl-2-pyrrolidinone hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) TMEDA, n-BuLi / 1.) THF, 0 deg C, 30 min, 2.) -78 deg C

2: 47 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 1.) -78 deg C, 1 h 2.) 4 deg C, 18 h

3: 100 percent / acetic acid; HBr / 20 h / Heating

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; hydrogen bromide; acetic acid; toluene;
DOI:10.1021/jo00005a042