3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester

Base Information

• Chemical Name: 3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester
• CAS No.: 50627-32-2
• Molecular Formula: C₁₄H₁₆N₂O₅
• Molecular Weight: 292.291
• Mol file: 50627-32-2.mol

Synonyms:3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester

Chemical Property of 3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester

There total 12 articles about 3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C14H17ClN2O5 (1294456-01-1) → 3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester (50627-32-2)

Guidance literature:

With potassium carbonate; potassium iodide; In methanol;

DOI:10.1016/j.tetlet.2011.01.138

Reference yield:

1-methylpiperazin-2,5-dione (5625-52-5) → 3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester (50627-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI, K₂CO₃ / nitrobenzene / 0.67 h / 170 °C

2: methanol; diethyl ether / Ambient temperature

With copper(l) iodide; potassium carbonate; In methanol; diethyl ether; nitrobenzene;

DOI:10.1016/S0040-4020(01)97960-8

Reference yield:

2-iodo-3-methoxybenzoic acid (50627-31-1) → 3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester (50627-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI, K₂CO₃ / nitrobenzene / 0.67 h / 170 °C

2: methanol; diethyl ether / Ambient temperature

With copper(l) iodide; potassium carbonate; In methanol; diethyl ether; nitrobenzene;

DOI:10.1016/S0040-4020(01)97960-8

upstream raw materials:

diazomethane

1-methylpiperazin-2,5-dione

2-iodo-3-methoxybenzoic acid

methyl 2-amino-3-methoxybenzoate

Downstream raw materials:

C₂₉H₂₈N₂O₅S₂

C₂₉H₂₈N₂O₅S₂

C₂₁H₂₀N₂O₅S₂

C₂₁H₂₀N₂O₅S₂