Methyl 2-aMino-3-Methoxybenzoate

Base Information

• Chemical Name: Methyl 2-aMino-3-Methoxybenzoate
• CAS No.: 5121-34-6
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Hs Code.: 2922509090
• Mol file: 5121-34-6.mol

Synonyms:Methyl 2-Amino-3-Methoxybenzoate

Chemical Property of Methyl 2-aMino-3-Methoxybenzoate

Chemical Property:

• Melting Point: 46.0 to 50.0 °C
• Boiling Point: 286.1 °C at 760 mmHg
• PKA: 2.13±0.10(Predicted)
• Flash Point: 133.4 °C
• PSA: 61.55000
• Density: 1.179 g/cm³
• LogP: 1.64520
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-Amino-3-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-aMino-3-Methoxybenzoate

There total 19 articles about Methyl 2-aMino-3-Methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-methoxyisatoic anhydride (34954-65-9) → methyl 2-amino-3-methoxybenzoate (5121-34-6)

Guidance literature:

With sodium hydroxide; for 2h; Reflux;

Reference yield: 99.0%

methyl 3-methoxy-2-nitrobenzoate (5307-17-5) → methyl 2-amino-3-methoxybenzoate (5121-34-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 18h;

Reference yield: 99.0%

2-amino-3-methoxybenzoic acid (3177-80-8) → methyl 2-amino-3-methoxybenzoate (5121-34-6)

Guidance literature:

N-Methyl-N'-nitro-N-nitrosoguanidine; With potassium hydroxide; In diethyl ether; water; at 0 ℃;

2-amino-3-methoxybenzoic acid; In diethyl ether; acetone;

upstream raw materials:

methyl 3-methoxy-2-nitrobenzoate

diazomethane

2-amino-3-methoxybenzoic acid

3-hydroxyanthranilic acid

Downstream raw materials:

2-Chloracetylamino-3-methoxy-benzoesaeure-methylester

2-Chloro-3-methoxybenzoic acid methyl ester

2-amino-5-chloro-3-methoxybenzoic acid

6-bromo-2,4-dichloro-8-methoxyquinazoline

Refernces

• 1、 Boelke, Andreas,Nachtsheim, Boris J.. "Evolution of N-Heterocycle-Substituted Iodoarenes (NHIAs) to Efficient Organocatalysts in Iodine(I/III)-Mediated Oxidative Transformations". supporting information. p. 184 - 191. Retrieved 2019/12/11.
• 2、 Reed, Carson W.,Kalbfleisch, Jacob J.,Wong, Madison J.,Washecheck, Jordan P.,Hunter, Ashton,Rodriguez, Alice L.,Blobaum, Anna L.,Conn, P. Jeffrey,Niswender, Colleen M.,Lindsley, Craig W.. "Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu7Positive Allosteric Modulator Tool Compound". supporting information. p. 1773 - 1779. Retrieved 2020/10/19.