(2S,2'R)-N-[2'-(methoxymethyl)pyrrolidin-1'-yl]-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide

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Chemical Name:(2S,2'R)-N-[2'-(methoxymethyl)pyrrolidin-1'-yl]-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide
CAS No.:506441-83-4
Molecular Formula:C₁₈H₂₃F₃N₂O₂
Molecular Weight:356.388
Hs Code.:

Synonyms:(2S,2'R)-N-[2'-(methoxymethyl)pyrrolidin-1'-yl]-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide

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Chemical Property of (2S,2'R)-N-[2'-(methoxymethyl)pyrrolidin-1'-yl]-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide

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Technology Process of (2S,2'R)-N-[2'-(methoxymethyl)pyrrolidin-1'-yl]-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide

There total 2 articles about (2S,2'R)-N-[2'-(methoxymethyl)pyrrolidin-1'-yl]-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 98-88-4
benzoyl chloride

: 506441-81-2
(2S,2'R)-2-[2'-(methoxymethyl)pyrrolidin-1'-yl]amino-1,1,1-trifluoropent-4-ene

: 506441-83-4
(2S,2'R)-N-[2'-(methoxymethyl)pyrrolidin-1'-yl]-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1055/s-2002-35631

Reference yield:

: 343614-73-3
trifluoroacetaldehyde (R)-SAMP hydrazone

: 506441-83-4
(2S,2'R)-N-[2'-(methoxymethyl)pyrrolidin-1'-yl]-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: PhLi / diethyl ether; cyclohexane / 20 °C

1.2: 67 percent / diethyl ether; cyclohexane / -78 °C

2.1: 61 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

With dmap; phenyllithium; triethylamine; In diethyl ether; dichloromethane; cyclohexane;
DOI:10.1055/s-2002-35631

Reference yield: 98.0%

: 506441-83-4
(2S,2'R)-N-[2'-(methoxymethyl)pyrrolidin-1'-yl]-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide

: (S)-N-(1,1,1-trifluoropent-4-en-2-yl)benzamide

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; samarium diiodide; In tetrahydrofuran; at 20 ℃;
DOI:10.1055/s-2002-35631