N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide trifluoroacetate

Base Information

• Chemical Name: N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide trifluoroacetate
• CAS No.: 1176753-94-8
• Molecular Formula: C₂HF₃O₂*C₁₄H₁₇F₃N₂O
• Molecular Weight: 400.321
• Mol file: 1176753-94-8.mol

Synonyms:N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide trifluoroacetate

Chemical Property of N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide trifluoroacetate

There total 1 articles about N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester (1141894-92-9) + trifluoroacetic acid (76-05-1) → N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide trifluoroacetate (1176753-94-8)

Guidance literature:

In dichloromethane; at 20 ℃; Product distribution / selectivity;

Reference yield: 4.0%

crimidine (535-89-7) + N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide trifluoroacetate (1176753-94-8) → 1-[4-(dimethylamino)-6-methyl-2-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (1176753-77-7)

Guidance literature:

With triethylamine; In ethanol; at 120 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide trifluoroacetate (1176753-94-8) → N-[[2-(trifluoromethyl)phenyl]methyl]-4-piperidinecarboxamide (1141894-80-5)

Guidance literature:

With sodium hydrogencarbonate; In water;

upstream raw materials:

4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester

trifluoroacetic acid

Downstream raw materials:

1-[4-(dimethylamino)-6-methyl-2-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

N-[[2-(trifluoromethyl)phenyl]methyl]-4-piperidinecarboxamide

1-(2-chloro-4-pyrimidinyl)-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidine carboxamide