4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester

Base Information

• Chemical Name: 4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester
• CAS No.: 1141894-92-9
• Molecular Formula: C₁₉H₂₅F₃N₂O₃
• Molecular Weight: 386.414
• Mol file: 1141894-92-9.mol

Synonyms:4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester

Chemical Property of 4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester

There total 3 articles about 4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

o-trifluoromethylbenzylamine (3048-01-9) + N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → 4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester (1141894-92-9)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → 4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester (1141894-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 1 h / 0 °C / Inert atmosphere

2: 12 h / 20 °C / Inert atmosphere

With triethylamine;

DOI:10.1039/c6md00042h

Reference yield:

o-trifluoromethylbenzylamine (3048-01-9) + C15H27NO4 → 4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester (1141894-92-9)

Guidance literature:

at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c6md00042h

upstream raw materials:

o-trifluoromethylbenzylamine

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

Downstream raw materials:

1-((1H-indazol-5-yl)sulfonyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide

1-[4-methyl-6-(morpholino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

1-[4-chloro-6-(methylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

1-[4-methyl-6-(isopropylamino)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide