(2R,3R,4S,5S,6S)-1-Benzyl-3,4,5-tris-benzyloxy-2-benzyloxymethyl-6-iodomethyl-piperidine

Base Information

Chemical Name:(2R,3R,4S,5S,6S)-1-Benzyl-3,4,5-tris-benzyloxy-2-benzyloxymethyl-6-iodomethyl-piperidine
CAS No.:176540-16-2
Molecular Formula:C₄₂H₄₄INO₄
Molecular Weight:753.72
Hs Code.:

Synonyms:(2R,3R,4S,5S,6S)-1-Benzyl-3,4,5-tris-benzyloxy-2-benzyloxymethyl-6-iodomethyl-piperidine

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Chemical Property of (2R,3R,4S,5S,6S)-1-Benzyl-3,4,5-tris-benzyloxy-2-benzyloxymethyl-6-iodomethyl-piperidine

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Technology Process of (2R,3R,4S,5S,6S)-1-Benzyl-3,4,5-tris-benzyloxy-2-benzyloxymethyl-6-iodomethyl-piperidine

There total 3 articles about (2R,3R,4S,5S,6S)-1-Benzyl-3,4,5-tris-benzyloxy-2-benzyloxymethyl-6-iodomethyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 176540-15-1
Benzyl-((1R,2R,3R,4S)-2,3,4-tris-benzyloxy-1-benzyloxymethyl-hex-5-enyl)-amine

: 176540-16-2
(2R,3R,4S,5S,6S)-1-Benzyl-3,4,5-tris-benzyloxy-2-benzyloxymethyl-6-iodomethyl-piperidine

Guidance literature:: With N-iodo-succinimide; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1016/0040-4039(96)00226-2

Reference yield:

: 79258-18-7
(2R,3R,4R,5S)-1,3,4,5-tetrakis(benzyloxy)hept-6-en-2-ol

: 176540-16-2
(2R,3R,4S,5S,6S)-1-Benzyl-3,4,5-tris-benzyloxy-2-benzyloxymethyl-6-iodomethyl-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DMSO, TFAA, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C

2: 1.) HOAc, 2.) NaBH₃CN / 1.) MeOH, RT, 2 h, 2.) MeOH, reflux, 4 h

3: 80 percent / NIS / CH₂Cl₂ / 3 h / Ambient temperature

With N-iodo-succinimide; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1016/0040-4039(96)00226-2

Reference yield:

: 110205-68-0
1,3,4,5-tetra-O-benzyl-6,7-dideoxy-L-xylo-hept-6-en-2-ulose

: 176540-16-2
(2R,3R,4S,5S,6S)-1-Benzyl-3,4,5-tris-benzyloxy-2-benzyloxymethyl-6-iodomethyl-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HOAc, 2.) NaBH₃CN / 1.) MeOH, RT, 2 h, 2.) MeOH, reflux, 4 h

2: 80 percent / NIS / CH₂Cl₂ / 3 h / Ambient temperature

With N-iodo-succinimide; sodium cyanoborohydride; acetic acid; In dichloromethane;
DOI:10.1016/0040-4039(96)00226-2