diphenylmethyl (6R, 7S)-7-(2'-thienyl)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

Base Information

Chemical Name:diphenylmethyl (6R, 7S)-7-(2'-thienyl)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate
CAS No.:35607-68-2
Molecular Formula:C₂₉H₂₇N₃O₇S₂
Molecular Weight:593.681
Hs Code.:

Synonyms:diphenylmethyl (6R, 7S)-7-(2'-thienyl)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

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Chemical Property of diphenylmethyl (6R, 7S)-7-(2'-thienyl)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

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MSDS Files:: SDS file from LookChem

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Technology Process of diphenylmethyl (6R, 7S)-7-(2'-thienyl)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

There total 7 articles about diphenylmethyl (6R, 7S)-7-(2'-thienyl)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 39098-97-0
2-thienylacetic acid chloride

: 52390-38-2
diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

: 35607-68-2
diphenylmethyl (6R, 7S)-7-(2'-thienyl)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

Guidance literature:: With N,N-dimethyl-aniline; In dichloromethane; at 0 ℃; for 15h;
DOI:10.1016/0040-4020(80)80149-9

Reference yield:

: 35664-28-9
(6R)-7t-[(R)-5-benzhydryloxycarbonyl-5-(2,2,2-trichloro-ethoxycarbonylamino)-pentanoylamino]-3-carbamoyloxymethyl-7c-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 35607-68-2
diphenylmethyl (6R, 7S)-7-(2'-thienyl)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Na₂CO₃, 2.) H₂O / 1.) dioxane, 5 deg C, then 20 deg C, 12 h, 2.) 1 h

2: 1.) PhN=C=NPh, 2.) N,N-dimethylaniline / 1.) CH₂Cl₂, 18 h, 0 deg C, 2.) CH₂Cl₂

With water; sodium carbonate; N,N-dimethyl-aniline; 1,3-Diphenylcarbodiimide;
DOI:10.1016/0040-4020(80)80149-9

Reference yield:

: 32178-84-0
cephamycin C

: 35607-68-2
diphenylmethyl (6R, 7S)-7-(2'-thienyl)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-trichloroethoxycarbonylation, 2.) benzhydryl esterification

2: 1.) Na₂CO₃, 2.) H₂O / 1.) dioxane, 5 deg C, then 20 deg C, 12 h, 2.) 1 h

3: 1.) PhN=C=NPh, 2.) N,N-dimethylaniline / 1.) CH₂Cl₂, 18 h, 0 deg C, 2.) CH₂Cl₂

With water; sodium carbonate; N,N-dimethyl-aniline; 1,3-Diphenylcarbodiimide;
DOI:10.1016/0040-4020(80)80149-9