diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

Base Information

Chemical Name:diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate
CAS No.:52390-38-2
Molecular Formula:C₂₃H₂₃N₃O₆S
Molecular Weight:469.518
Hs Code.:

Synonyms:diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

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Chemical Property of diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

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Technology Process of diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

There total 5 articles about diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 66893-40-1
diphenylmethyl (6R,7S)-7-carboxycarbonylamino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

: 6488-59-1
diphenylparabanic acid

: 52390-38-2
diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

Guidance literature:: With 1,3-Diphenylcarbodiimide; In dichloromethane; at 0 ℃; for 18h;
DOI:10.1016/0040-4020(80)80149-9

Reference yield:

: 35664-28-9
(6R)-7t-[(R)-5-benzhydryloxycarbonyl-5-(2,2,2-trichloro-ethoxycarbonylamino)-pentanoylamino]-3-carbamoyloxymethyl-7c-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 52390-38-2
diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Na₂CO₃, 2.) H₂O / 1.) dioxane, 5 deg C, then 20 deg C, 12 h, 2.) 1 h

2: 56 percent / diphenylcarbodiimide / CH₂Cl₂ / 18 h / 0 °C

With water; sodium carbonate; 1,3-Diphenylcarbodiimide; In dichloromethane;
DOI:10.1016/0040-4020(80)80149-9

Reference yield:

: 68318-53-6
(6R)-7t-hydroxyoxalylamino-3-(hydroxyoxalylcarbamoyloxy-methyl)-7c-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 52390-38-2
diphenylmethyl (6R, 7S)-7-amino-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / H₂O, conc. HCl / acetone / 72 h / Ambient temperature

2: 56 percent / diphenylcarbodiimide / CH₂Cl₂ / 18 h / 0 °C

With hydrogenchloride; water; 1,3-Diphenylcarbodiimide; In dichloromethane; acetone;
DOI:10.1016/0040-4020(80)80149-9