Technology Process of cephamycin C
There total 1 articles about cephamycin C which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Streptomyces Lactamdurans (MA 2908);
- Guidance literature:
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Multi-step reaction with 4 steps
1: 1.) N-trichloroethoxycarbonylation, 2.) benzhydryl esterification
2: 1.) Na2CO3, 2.) H2O / 1.) dioxane, 5 deg C, then 20 deg C, 12 h, 2.) 1 h
3: 1.) PhN=C=NPh, 2.) N,N-dimethylaniline / 1.) CH2Cl2, 18 h, 0 deg C, 2.) CH2Cl2
4: 56 percent / CF3COOH / various solvent(s) / 1.) -30 deg C, 2.) -20 deg C, 20 min, 3.) -10 deg C, 20 min
With
water; sodium carbonate; N,N-dimethyl-aniline; 1,3-Diphenylcarbodiimide; trifluoroacetic acid;
In
various solvent(s);
DOI:10.1016/0040-4020(80)80149-9
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) N-trichloroethoxycarbonylation, 2.) benzhydryl esterification
2: 1.) Na2CO3, 2.) H2O / 1.) dioxane, 5 deg C, then 20 deg C, 12 h, 2.) 1 h
3: 1.) PhN=C=NPh, 2.) N,N-dimethylaniline / 1.) CH2Cl2, 18 h, 0 deg C, 2.) CH2Cl2
With
water; sodium carbonate; N,N-dimethyl-aniline; 1,3-Diphenylcarbodiimide;
DOI:10.1016/0040-4020(80)80149-9