2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine

Base Information

• Chemical Name: 2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine
• CAS No.: 1332875-16-7
• Molecular Formula: C₂₁H₁₉F₃N₄O₂
• Molecular Weight: 416.403
• Mol file: 1332875-16-7.mol

Synonyms:2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine

Chemical Property of 2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine

There total 7 articles about 2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide (1332875-15-6) → 2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine (1332875-16-7)

Guidance literature:

3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide; With iron; acetic acid; at 100 ℃; for 3h;

With sodium hydrogencarbonate; In water;

Reference yield:

3-tert-butylisoxazole-5-carboxylic acid (133674-40-5) → 2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine (1332875-16-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2: tetrahydrofuran; mineral oil / 1 h / 20 °C

3: iron / acetic acid / 3 h / 100 °C

With oxalyl dichloride; iron; N,N-dimethyl-formamide; acetic acid; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

2,6-dichloro-3-nitropyridin-4-amine (2897-43-0) → 2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine (1332875-16-7)

Guidance literature:

Multi-step reaction with 5 steps

1: methanol / 2 h / 100 °C / Sealed tube

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 15 h / 80 °C / Inert atmosphere

3: tetrahydrofuran; mineral oil / 1 h / 20 °C

4: tetrahydrofuran; mineral oil / 1 h / 20 °C

5: iron / acetic acid / 3 h / 100 °C

With iron; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; mineral oil; 2: Suzuki Coupling;

upstream raw materials:

3-tert-butylisoxazole-5-carboxylic acid

2,6-dichloro-3-nitropyridin-4-amine

3-tert-butyl-isoxazole-5-carbonyl chloride

6-chloro-2-methoxy-3-nitro-pyridin-4-ylamine