3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide

Base Information

• Chemical Name: 3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide
• CAS No.: 1332875-15-6
• Molecular Formula: C₂₁H₁₉F₃N₄O₅
• Molecular Weight: 464.401
• Mol file: 1332875-15-6.mol

Synonyms:3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide

Chemical Property of 3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide

There total 5 articles about 3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-tert-butyl-isoxazole-5-carbonyl chloride (1196104-05-8) + C13H9F3N3O3(1-)*Na(1+) → 3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide (1332875-15-6)

Guidance literature:

In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

Reference yield:

2,6-dichloro-3-nitropyridin-4-amine (2897-43-0) → 3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide (1332875-15-6)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol / 2 h / 100 °C / Sealed tube

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 15 h / 80 °C / Inert atmosphere

3: tetrahydrofuran; mineral oil / 1 h / 20 °C

4: tetrahydrofuran; mineral oil / 1 h / 20 °C

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; mineral oil; 2: Suzuki Coupling;

Reference yield:

6-chloro-2-methoxy-3-nitro-pyridin-4-ylamine (1332875-13-4) → 3-tert-butyl-isoxazole-5-carboxylic acid [2-methoxy-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide (1332875-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 15 h / 80 °C / Inert atmosphere

2: tetrahydrofuran; mineral oil / 1 h / 20 °C

3: tetrahydrofuran; mineral oil / 1 h / 20 °C

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; water; mineral oil; 1: Suzuki Coupling;

upstream raw materials:

3-tert-butylisoxazole-5-carboxylic acid

2,6-dichloro-3-nitropyridin-4-amine

3-tert-butyl-isoxazole-5-carbonyl chloride

6-chloro-2-methoxy-3-nitro-pyridin-4-ylamine

Downstream raw materials:

2-(3-tert-butyl-isoxazol-5-yl)-4-methoxy-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]-pyridine