ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate

Base Information

Chemical Name:ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate
CAS No.:1609250-81-8
Molecular Formula:C₂H₂O₄*C₁₇H₁₉NO₄
Molecular Weight:391.378
Hs Code.:

Synonyms:ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate

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Chemical Property of ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate

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Technology Process of ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate

There total 7 articles about ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144-62-7,97993-78-7
oxalic acid

: 87307-83-3
ethyl 3-<4-<3-methoxy-2-(phenylmethoxy)phenyl>pyridin-3-yl>propenoate

: 1609250-81-8
ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate

Guidance literature:: ethyl 3-<4-<3-methoxy-2-(phenylmethoxy)phenyl>pyridin-3-yl>propenoate; With palladium on activated charcoal; hydrogen; for 0.5h; under 3102.97 Torr;

oxalic acid; In acetone; Heating;
DOI:10.1021/jo500568s

Reference yield:

: 2011-06-5
2-benzyloxy-3-methoxybenzaldehyde

: 1609250-81-8
ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether / -78 - -10 °C / Inert atmosphere

2.1: manganese(IV) oxide / 1,2-dichloro-ethane / 1.5 h / Reflux

3.1: toluene / 0.25 h / -20 - -15 °C / Inert atmosphere

4.1: oxalyl dichloride / chloroform / 3 h / 15 - 25 °C / Reflux; Inert atmosphere

4.2: 25 °C / pH 4.0

5.1: sodium; ethanol / 0.17 h / 23 °C

5.2: 0.5 h / 20 - 25 °C

6.1: palladium on activated charcoal; hydrogen / 0.5 h / 3102.97 Torr

6.2: Heating

With manganese(IV) oxide; oxalyl dichloride; ethanol; palladium on activated charcoal; hydrogen; sodium; In diethyl ether; chloroform; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo500568s

Reference yield:

: 87307-77-5
1-<3-methoxy-2-(phenylmethoxy)phenyl>ethanone

: 1609250-81-8
ethyl 3-(4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl)propanoate oxalate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 0.25 h / -20 - -15 °C / Inert atmosphere

2.1: oxalyl dichloride / chloroform / 3 h / 15 - 25 °C / Reflux; Inert atmosphere

2.2: 25 °C / pH 4.0

3.1: sodium; ethanol / 0.17 h / 23 °C

3.2: 0.5 h / 20 - 25 °C

4.1: palladium on activated charcoal; hydrogen / 0.5 h / 3102.97 Torr

4.2: Heating

With oxalyl dichloride; ethanol; palladium on activated charcoal; hydrogen; sodium; In chloroform; toluene;
DOI:10.1021/jo500568s