87307-77-5Relevant academic research and scientific papers
COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR
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, (2017/08/01)
The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.
Preparation technology of 1-(2-hydroxy-3-methoxyphenyl)ethanone
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Paragraph 0016; 0021-0042; 0046; 0051-0072; 0076; 0081-0092, (2017/08/27)
The invention discloses a preparation technology of 1-(2-hydroxy-3-methoxyphenyl)ethanone. Through protecting group addition, alkylation, oxidation and deprotection, 1-(2-hydroxy-3-methoxyphenyl)ethanone is prepared from o-vanillin as a raw material. The
Synthesis of enantiopure 10-nornaltrexones in the search for toll-like receptor 4 antagonists and opioid ligands
Selfridge, Brandon R.,Deschamps, Jeffrey R.,Jacobson, Arthur E.,Rice, Kenner C.
, p. 5007 - 5018 (2014/06/23)
10-Nornaltrexones (3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6- hexahydro-1H-benzofuro[3,2-e]isoquinolin-7(7aH)-one, 1) have been underexploited in the search for better opioid ligands, and their enantiomers have been unexplored. The synthesis of tr
Synthesis and structure-activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents
Murata, Toshiki,Shimada, Mitsuyuki,Sakakibara, Sachiko,Yoshino, Takashi,Masuda, Tsutomu,Shintani, Takuya,Sato, Hiroki,Koriyama, Yuji,Fukushima, Keiko,Nunami, Noriko,Yamauchi, Megumi,Fuchikami, Kinji,Komura, Hiroshi,Watanabe, Akihiko,Ziegelbauer, Karl B.,Bacon, Kevin B.,Lowinger, Timothy B.
, p. 4019 - 4022 (2007/10/03)
A series of 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl)pyridine derivatives was synthesized and evaluated as IκB kinase β (IKK-β) inhibitors. Modification of a novel IKK-β inhibitor 1 (IKK-β IC 50=1500nM, Cell IC50=8000nM) at the 4-p
Alternate and improved synthesis of the cactus alkaloid arizonine
Kaufman
, p. 1913 - 1921 (2007/10/02)
An alternate and high-yield synthesis of the simple tetrahydroisoquinoline alkaloid arizonine, via the sodium cyanoborohydride mediated reductive amination of 2-benzyloxy-3-methoxyacetophenone with aminoacetaldehyde diethyl acetal, as the key step, is rep
Synthesis of 3-Methyl-5,6-dihydro-3H-benzofuroisoquinolin-7(7aH)-ones
Weller, Dwight D.,Stirchak, Eugene P.,Weller, Doreen L.
, p. 4597 - 4605 (2007/10/02)
The coupling of 2-(alkoxymethoxy)phenylcopper derivatives with the salt of ethyl chloroformate and ethyl 3-(pyridin-3-yl)propenoate was found to be an efficient method for the preparation of 4-(2-hydroxyphenyl)pyridines 13 substituted at C-3 with a propanoate side chain.N-Methylation and O-alkylation with ethyl bromoacetate gave salts 3 which when treated with base underwent an intramolecular enolate addition to the pyridinium nucleus to produce spiro 4.Prolonged base treatment of 4 yielded ethyl 3-methyl-7-hydroxy-5,7a-dihydro-3H-benzofuroisoquinoline-6-carboxylates 5 by a Dieckmann reaction.Reduction of 5 led to predominately trans-3-methylhexahydro-1H-benzofuroisoquinolin-7(7aH)-ones, while reduction of 4 and then Dieckmann cyclization yielded mainly the cis isomers.
