(S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one

Base Information Edit

Chemical Name:(S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one
CAS No.:953805-20-4
Molecular Formula:C₂₅H₂₈FNO₅
Molecular Weight:441.499
Hs Code.:
Mol file:953805-20-4.mol

Synonyms:3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one

Suppliers and Price of (S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

TRC
(4S)-3-[4-[2-(4-Fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-1-oxobutyl]-4-phenyl-2-oxazolidinone
250mg
$ 990.00

TRC
(4S)-3-[4-[2-(4-Fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-1-oxobutyl]-4-phenyl-2-oxazolidinone
50mg
$ 250.00

Crysdot
(S)-3-(4-(2-(4-Fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one 97%
1g
$ 1191.00

Total 0 raw suppliers

Chemical Property of (S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one Edit

Chemical Property:

Purity/Quality:: (4S)-3-[4-[2-(4-Fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-1-oxobutyl]-4-phenyl-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (4S)-3-[4-[2-(4-Fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-1-oxobutyl]-4-phenyl-2-oxazolidinone is an intermediate in the synthesis of (3’R,3R,4R)-Ezetimibe (E974990), a structural analog of Ezetimibe (E975000). Ezetimibe is an antihyperlipoproteinemic and a cholesterol absorption inhibitor.

Technology Process of (S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one

There total 6 articles about (S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 189028-93-1,404874-93-7
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

: 953805-20-4
3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one

Guidance literature:: With phosphorus pentoxide; sulfuric acid; In dichloromethane; for 5h; Reflux;

Reference yield:

: C₂₁H₂₉FO₅

: 99395-88-7,7480-32-2
(S)-4-phenyl-2-oxazolidinone

: 953805-20-4
3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one

Guidance literature:: C₂₁H₂₉FO₅; (S)-4-phenyl-2-oxazolidinone; With dmap; In dichloromethane; N,N-dimethyl-formamide; at 20 - 25 ℃; for 7h; Heating / reflux;

With sulfuric acid; In dichloromethane; N,N-dimethyl-formamide; at 20 - 25 ℃; Product distribution / selectivity;

Reference yield:

: 953805-21-5
4-(2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl)butanoic acid

: 953805-20-4
3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: lithium chloride / dichloromethane / 7 h / Inert atmosphere; Heating

With triethylamine; lithium chloride; In dichloromethane;
DOI:10.1016/j.tetlet.2013.09.049