N-(1,2-dihydro-2-oxo-3-pyridinyl)-N-(2-methoxy-1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide

Base Information

Chemical Name:N-(1,2-dihydro-2-oxo-3-pyridinyl)-N-(2-methoxy-1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide
CAS No.:112777-33-0
Molecular Formula:C₁₈H₁₈F₃N₃O₄
Molecular Weight:397.354
Hs Code.:

Synonyms:N-(1,2-dihydro-2-oxo-3-pyridinyl)-N-(2-methoxy-1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide

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Chemical Property of N-(1,2-dihydro-2-oxo-3-pyridinyl)-N-(2-methoxy-1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide

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Technology Process of N-(1,2-dihydro-2-oxo-3-pyridinyl)-N-(2-methoxy-1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide

There total 5 articles about N-(1,2-dihydro-2-oxo-3-pyridinyl)-N-(2-methoxy-1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20265-38-7
3-amino-2-methoxypyridine

: 112777-33-0
N-(1,2-dihydro-2-oxo-3-pyridinyl)-N-(2-methoxy-1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide

Guidance literature:: Multi-step reaction with 4 steps

1: 17.8 g / MgSO₄ / benzene / 1) 2 h reflux 2) stirring at room teperature overnight

2: 41 percent / NaBH₄ / ethanol / 16 h / Heating

3: 71 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature

4: 1) gaseous HCl 2) 4-vinylpyridine polymer / 1) benzene, 72 h, room temperature 2) ethyl acetate, reflux 72 h

With hydrogenchloride; sodium tetrahydroborate; 4-vinylpyridine polymer; sodium hydride; magnesium sulfate; In tetrahydrofuran; ethanol; benzene;
DOI:10.1002/jhet.5570240403

Reference yield:

: 20265-35-4
2-methoxy-3-nitropyridine

: 112777-33-0
N-(1,2-dihydro-2-oxo-3-pyridinyl)-N-(2-methoxy-1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / H₂ / sulfided platinum / ethanol / 8 h / 150 °C / 51714.8 Torr

2: 1) gaseous HCl 2) 4-vinylpyridine polymer / 1) benzene, 72 h, room temperature 2) ethyl acetate, reflux 72 h

With hydrogenchloride; 4-vinylpyridine polymer; hydrogen; sulfided platinum; In ethanol;
DOI:10.1002/jhet.5570240403

Reference yield:

: 112777-35-2
2-methoxy-N-(2-hydroxy-1-methylethyl)-3-aminopyridine

: 112777-33-0
N-(1,2-dihydro-2-oxo-3-pyridinyl)-N-(2-methoxy-1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature

2: 1) gaseous HCl 2) 4-vinylpyridine polymer / 1) benzene, 72 h, room temperature 2) ethyl acetate, reflux 72 h

With hydrogenchloride; 4-vinylpyridine polymer; sodium hydride; In tetrahydrofuran;
DOI:10.1002/jhet.5570240403