ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate

Base Information

Chemical Name:ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate
CAS No.:86712-04-1
Molecular Formula:C₂₂H₁₇ClFN₃O₂
Molecular Weight:409.847
Hs Code.:

Synonyms:ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate

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Chemical Property of ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate

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Technology Process of ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate

There total 5 articles about ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58583-07-6
8-chloro-1-(2-fluorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one

: 86712-04-1
ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / dimethylformamide / 2 h / 80 - 85 °C

2: 76 percent / sodium methoxide / methanol; CH₂Cl₂ / Ambient temperature

3: 83 percent / aq. H₂SO₄ / 12 h / Heating

4: 73 percent / POCl₃ / 4 h / 100 °C

5: 1.) potassium tert-butoxide / 2.) 15 min, 2.) a) 110 deg C, 2 h, b) 140 deg C, 4 h

With sulfuric acid; potassium tert-butylate; sodium methylate; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00365a008

Reference yield:

: 58582-30-2
8-chloro-1-(2-fluorophenyl)-3,4-dihydro-4-[(dimethylamino)methylene]-5H-2-benzazepin-5-one

: 86712-04-1
ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / sodium methoxide / methanol; CH₂Cl₂ / Ambient temperature

2: 83 percent / aq. H₂SO₄ / 12 h / Heating

3: 73 percent / POCl₃ / 4 h / 100 °C

4: 1.) potassium tert-butoxide / 2.) 15 min, 2.) a) 110 deg C, 2 h, b) 140 deg C, 4 h

With sulfuric acid; potassium tert-butylate; sodium methylate; trichlorophosphate; In methanol; dichloromethane;
DOI:10.1021/jm00365a008

Reference yield:

: 76988-53-9
9-chloro-7-(2-fluorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-2-ol

: 86712-04-1
ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / POCl₃ / 4 h / 100 °C

2: 1.) potassium tert-butoxide / 2.) 15 min, 2.) a) 110 deg C, 2 h, b) 140 deg C, 4 h

With potassium tert-butylate; trichlorophosphate;
DOI:10.1021/jm00365a008