58582-30-2Relevant academic research and scientific papers
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
Sells, Todd B.,Chau, Ryan,Ecsedy, Jeffrey A.,Gershman, Rachel E.,Hoar, Kara,Huck, Jessica,Janowick, David A.,Kadambi, Vivek J.,Leroy, Patrick J.,Stirling, Matthew,Stroud, Stephen G.,Vos, Tricia J.,Weatherhead, Gabriel S.,Wysong, Deborah R.,Zhang, Mengkun,Balani, Suresh K.,Bolen, Joseph B.,Manfredi, Mark G.,Claiborne, Christopher F.
, p. 630 - 634 (2015/06/30)
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective,
2-Benzazepines. 5. Synthesis of pyrimido[5,4-d][2]benzazepines and their evaluation as anxiolytic agents
Trybulski, Eugene J.,Benjamin, Louis E.,Earley, James V.,Fryer, R. Ian,Gilman, Norman W.,et al.
, p. 1589 - 1596 (2007/10/02)
A series of 5H-pyrimido[5,4-d][2]benzazepines has been synthesized, starting from the corresponding 2-benzazepine-5-ones, and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different
Intermediates in the production of 2-benzazepines
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, (2008/06/13)
Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ
2-Pyrazolyl-benzophenones
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, (2008/06/13)
2-Pyrazolyl-benzophenones, e.g. those of the formula STR1 R = H or alkyl Ro = H, alkyl, (HO, alkoxy, amino)-alkyl, aralkyl, or aryl R', r" = h, alkyl, alkoxy, halo or CF3 Am = open or cyclic amino Corresponding ketals, or therapeutically useful acid addition salts thereof exhibit antianxiety and antidepressant effects.
2-Pyrazolyl-benzophenones
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, (2008/06/13)
2-Pyrazolyl-benzophenones, e.g. those of the formula STR1 CORRESPONDING KETALS, CARBINOLS, ACYL DERIVATIVES OR THERAPEUTICALLY USEFUL ACID ADDITION SALTS THEREOF EXHIBIT ANTIANXIETY AND ANTI-DEPRESSANT EFFECTS.
Pyrazolobenzazepines
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, (2008/06/13)
6-Aryl-1- or 2H,4H-pyrazolo[4,3-d](2)-benzazepines, e.g. those of the formula STR1 R = H or alkyl R° = H, alkyl, (HO, alkoxy, amino)-alkyl, aralkyl, aryl or acyl, R' = h, oh or alkyl R" = h, alkyl, alkoxy, halo or CF3 N-oxides thereof or therapeutically useful acid addition salts of such compounds exhibit antianxiety and antidepressant effects.
Pyrazolobenzazepines
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, (2008/06/13)
6-Aryl-1- or 2H,4H-pyrazolo[4,3-d](2) -benzazepines, e.g. those of the formula STR1 N-oxides thereof or therapeutically useful acid addition salts of such compounds exhibit antianxiety and antidepressant effects.
Pyrazolobenzazepines
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, (2008/06/13)
6-Aryl-1 or 2H,4H-pyrazolo[4,3-d](2)-benzazepines, e.g. those of the formula SPC1 R = h or alkyl Ro = H, alkyl, (HO, alkoxy, amino)-alkyl, aralkyl or aryl R' = h, oh or alkyl R" = h, alkyl, alkoxy, halo or CF3 5,6-dihydro- or 5-alkyl
Antidepressive and antianxiety composition comprising 2-pyrazolyl-benzophenones
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, (2008/06/13)
2-Pyrazolyl-benzophenones, e.g. those of the formula SPC1 Ro = H, alkyl, (HO, alkoxy, amino)- alkyl, aralkyl or aryl R = h or alkyl R',r" = h, alkyl,alkoxy, halo or CF3 Am = open or cyclic amino group Corresponding ketals, carbinols,
