58583-07-6

Upstream product

• 76049-49-5 (5-chloro-2-iodophenyl)(2-fluorophenyl)methanone 
• 869366-53-0 tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 
• 76049-53-1 1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-phthalimidopropyne 
• 76049-63-3 3-Amino-1-[4-chloro-2-(2-fluorobenzoyl)phenyl]propyne 
• 869366-08-5 [3-[4-chloro-2-(2-fluorobenzoyl)-phenyl]-3-oxopropyl]-carbamic acid tert-butyl ester 

Downstream Products

• 58582-30-2 8-chloro-1-(2-fluorophenyl)-3,4-dihydro-4-[(dimethylamino)methylene]-5H-2-benzazepin-5-one 
• 58582-30-2 8-Chloro-4-[1-dimethylamino-meth-(E)-ylidene]-1-(2-fluoro-phenyl)-3,4-dihydro-benzo[c]azepin-5-one 
• 86712-04-1 ethyl 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetate 
• 76988-57-3 9-chloro-7-(2-fluorophenyl)-N-[3-(dimethylamino)propyl]-5H-pyrimido[5,4-d][2]benzazepin-2-amine 
• 86712-06-3 9-chloro-7-(2-fluorophenyl)-N-methyl-5H-pyrimido[5,4-d][2]benzazepine-2-acetamide 
• 86712-05-2 9-chloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine-2-acetic acid 
• 76988-56-2 9-chloro-N,N-dimethyl-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-amine 
• 76988-55-1 9-chloro-7-(2-fluorophenyl)-N-methyl-5H-pyrimido[5,4-d][2]benzazepin-2-amine 
• 76988-58-4 9-chloro-2-methoxy-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine 
• 76988-60-8 9-chloro-7-(2-fluoropheny)-5H-pyrimido[5,4-d][2]benzazepine 6-oxide 
• 76988-22-2 BBL₂₂ 
• 76988-54-0 2,9-dichloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine 
• 76988-53-9 9-chloro-7-(2-fluorophenyl)-5H-pyrimido<5,4-d><2>benzazepin-2-ol 
• 76988-25-5 9-chloro-7-(2-fluorophenyl)-2-methyl-5H-pyrimido[5,4-d][2]benzazepine 

Relevant academic research and scientific papers

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

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Compounds and methods for inhibiting mitotic progression

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N-oxides of 5-oxo-1-phenyl-2-benzazepines

Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ

2-Benzazepines. 1. Synthesis of 2-Benzazepin-4-ones and -5-ones via 2-Acetylenic Benzophenones

The preparation of 1-phenyl-2-benzazepin-4-ones and -5-ones is discussed.The palladium-catalyzed coupling of an iodobenzophenone to a monosubstituted acetylene assembles the necessary atoms required for the benzazepine ring.Transformation of the acetylene

Intermediates in the production of 2-benzazepines

Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ

2-Pyrazolyl-benzophenones

2-Pyrazolyl-benzophenones, e.g. those of the formula STR1 R = H or alkyl Ro = H, alkyl, (HO, alkoxy, amino)-alkyl, aralkyl, or aryl R', r" = h, alkyl, alkoxy, halo or CF3 Am = open or cyclic amino Corresponding ketals, or therapeutically useful acid addition salts thereof exhibit antianxiety and antidepressant effects.

2-Pyrazolyl-benzophenones

2-Pyrazolyl-benzophenones, e.g. those of the formula STR1 CORRESPONDING KETALS, CARBINOLS, ACYL DERIVATIVES OR THERAPEUTICALLY USEFUL ACID ADDITION SALTS THEREOF EXHIBIT ANTIANXIETY AND ANTI-DEPRESSANT EFFECTS.

Antidepressive and antianxiety composition comprising 2-pyrazolyl-benzophenones

2-Pyrazolyl-benzophenones, e.g. those of the formula SPC1 Ro = H, alkyl, (HO, alkoxy, amino)- alkyl, aralkyl or aryl R = h or alkyl R',r" = h, alkyl,alkoxy, halo or CF3 Am = open or cyclic amino group Corresponding ketals, carbinols,