O-1492

Base Information

• Chemical Name: O-1492
• CAS No.: 50370-57-5
• Molecular Formula: C₁₆H₂₀FNO₂
• Molecular Weight: 277.339
• Mol file: 50370-57-5.mol

Synonyms:O-1492

Chemical Property of O-1492

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-1492

There total 7 articles about O-1492 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

4-flourophenylmagnesium bromide (352-13-6) + methyl ecgonidine (50373-10-9) → 2β-carbomethoxy-3β-(4-fluorophenyl)tropane (50370-59-7) + O-1492 (50370-57-5)

Guidance literature:

In diethyl ether; dichloromethane; at -40 ℃; for 3.5h;

DOI:10.1002/jhet.5570330676

Reference yield:

→ [3H]-(–)-2-b-carbomethoxy-3-b-(4-fluorophenyl)tropane. (50370-56-4,50370-57-5,50370-59-7,50373-04-1)

Guidance literature:

wie 24, p-Fluorphenylmagnesiumbromid, Cu2Cl2, chrom. Trennung von 26;

DOI:10.1021/jm00269a600

Reference yield:

→ (-)-Methyl-3β-(p-fluorophenyl)-1αH,5αH-tropane-2α-carboxylate (50370-56-4,50370-57-5,50370-59-7,50373-04-1)

Guidance literature:

wie 24, chrom. Trennung von 25;

DOI:10.1021/jm00269a600

upstream raw materials:

4-flourophenylmagnesium bromide

methyl ecgonidine

2β-carbomethoxy-3β-(4-fluorophenyl)tropane

Cocaine

Downstream raw materials:

(1R,2R,3S,5S)-2-(Benzo[1,3]dioxol-5-yloxymethyl)-3-(4-fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane

(1R,2R,3S)-2-hydroxymethyl-3-(4-fluorophenyl)tropane

Refernces

• 1、 Tamiz, Amir P.,Smith, Miles P.,Kozikowski, Alan P.. "Design, synthesis and biological evaluation of 7-azatricyclodecanes: Analogues of cocaine". . p. 297 - 300. Retrieved 2007/10/03.
• 2、 Xu,Trudell. "Stereoselective synthesis of 2β-carbomethoxy-3β-phenyltropane derivatives. Enhanced stereoselectivity observed for the conjugate addition reaction of phenylmagnesium bromide derivatives with anhydro dichloromethane". . p. 2037 - 2039. Retrieved 2007/10/03.