4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal

Base Information

Chemical Name:4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal
CAS No.:876017-52-6
Molecular Formula:C₃₂H₄₀O₅
Molecular Weight:504.667
Hs Code.:

Synonyms:4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal

Suppliers and Price of 4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal

There total 9 articles about 4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 367951-85-7
3α-benzyloxy-5β-estr-15-en-17-one

: 83953-42-8
4-bromo-2-furancarboxyaldehyde ethylene acetal

: 876017-52-6
4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal

Guidance literature:: 4-bromo-2-furancarboxyaldehyde ethylene acetal; With n-butyllithium; In tetrahydrofuran; at -70 ℃; for 0.5h;

3α-benzyloxy-5β-estr-15-en-17-one; In tetrahydrofuran; at -70 ℃; for 1h;
DOI:10.1021/jm0505819

Reference yield:

: 876017-48-0
3-oxo-5β-estrane-17-ethylene ketal

: 876017-52-6
4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3.0 g / NaBH₄ / methanol; tetrahydrofuran / 20 °C

2.1: 78 percent / NaH / toluene / 6 h / Heating

3.1: pyridinium tribromide / tetrahydrofuran / 20 h / 4 °C

4.1: t-BuOK / benzene; dimethylsulfoxide / 20 h / 60 °C

5.1: 3.4 g / pyridinium p-toluenesulfonate; H₂O / acetone

6.1: n-BuLi / tetrahydrofuran / 0.5 h / -70 °C

6.2: 40 percent / tetrahydrofuran / 1 h / -70 °C

With sodium tetrahydroborate; n-butyllithium; potassium tert-butylate; water; pyridinium p-toluenesulfonate; sodium hydride; pyridinium hydrobromide perbromide; In tetrahydrofuran; methanol; dimethyl sulfoxide; acetone; toluene; benzene;
DOI:10.1021/jm0505819

Reference yield:

: 876017-49-1
3α-hydroxy-5β-estrane-17-ethylene ketal

: 876017-52-6
4-(3'α-benzyloxy-17'-hydroxy-5'β-estr-15'-en-17'-yl)furan-2-carboxyaldehyde ethylene acetal

Guidance literature:: Multi-step reaction with 5 steps

1.1: 78 percent / NaH / toluene / 6 h / Heating

2.1: pyridinium tribromide / tetrahydrofuran / 20 h / 4 °C

3.1: t-BuOK / benzene; dimethylsulfoxide / 20 h / 60 °C

4.1: 3.4 g / pyridinium p-toluenesulfonate; H₂O / acetone

5.1: n-BuLi / tetrahydrofuran / 0.5 h / -70 °C

5.2: 40 percent / tetrahydrofuran / 1 h / -70 °C

With n-butyllithium; potassium tert-butylate; water; pyridinium p-toluenesulfonate; sodium hydride; pyridinium hydrobromide perbromide; In tetrahydrofuran; dimethyl sulfoxide; acetone; toluene; benzene;
DOI:10.1021/jm0505819