1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carbaldehyde

Base Information

Chemical Name:1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carbaldehyde
CAS No.:124021-61-0
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carbaldehyde

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Chemical Property of 1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carbaldehyde

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Technology Process of 1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carbaldehyde

There total 4 articles about 1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 124021-60-9
1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carboxylic acid tert-butyl ester

: 124021-61-0
1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carbaldehyde

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 0.75h;
DOI:10.1021/jo00286a007

Reference yield:

: 100-39-0
benzyl bromide

: 124021-61-0
1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 3 h

2: 89 percent / lithium aluminum hydride / diethyl ether / 0.75 h / 0 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00286a007

Reference yield:

: 117917-45-0
8,9-Dimethoxy-1-oxo-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carboxylic acid tert-butyl ester

: 124021-61-0
1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / sodium cyanoborohydride / acetic acid / 1.5 h / 0 - 20 °C

2: NaH / tetrahydrofuran / 3 h

3: 89 percent / lithium aluminum hydride / diethyl ether / 0.75 h / 0 °C

With lithium aluminium tetrahydride; sodium hydride; sodium cyanoborohydride; In tetrahydrofuran; diethyl ether; acetic acid;
DOI:10.1021/jo00286a007