2-(2-CHLORO-ACETYLAMINO)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-(2-CHLORO-ACETYLAMINO)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 6125-37-7
• Molecular Formula: C₉H₁₁ClN₂O₃S
• Molecular Weight: 262.717
• Mol file: 6125-37-7.mol

Synonyms:2-(2-chloroacetylamino)-4-methylthiazole-5-carboxylic acid ethyl ester

Chemical Property of 2-(2-CHLORO-ACETYLAMINO)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Chloro-acetylamino)-4-methyl-thiazole-5-carboxylic acid ethyl ester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

• Uses: 2-Chloroacetamido-4-methyl-5-carbethoxythiazole can be used as a pesticide. It can also be used for neoplasm inhibition for anti-tumoral activity.

Technology Process of 2-(2-CHLORO-ACETYLAMINO)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

There total 5 articles about 2-(2-CHLORO-ACETYLAMINO)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl-2-amino-4-methylthiazole-5-carboxylate (7210-76-6) + chloroacetyl chloride (79-04-9) → 2-(2-chloroacetylamino)-4-methylthiazole-5-carboxylic acid ethyl ester (6125-37-7)

Guidance literature:

ethyl-2-amino-4-methylthiazole-5-carboxylate; With potassium carbonate; In dichloromethane; at 20 ℃; for 0.5h;

chloroacetyl chloride; In dichloromethane; at 20 ℃;

Reference yield:

ethyl-2-amino-4-methylthiazole-5-carboxylate (7210-76-6) → 2-(2-chloroacetylamino)-4-methylthiazole-5-carboxylic acid ethyl ester (6125-37-7)

Guidance literature:

With chloroacetyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2018.10.008

Reference yield:

ethyl 2-chloro-3-oxo-butyrate (609-15-4) → 2-(2-chloroacetylamino)-4-methylthiazole-5-carboxylic acid ethyl ester (6125-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 3 h / Reflux

2: chloroacetyl chloride / N,N-dimethyl-formamide / 6 h / 20 °C

With chloroacetyl chloride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2018.10.008

upstream raw materials:

ethyl-2-amino-4-methylthiazole-5-carboxylate

chloroacetyl chloride

ethyl acetoacetate

ethyl 2-chloro-3-oxo-butyrate

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