N-(p-tolyl)-3-hydroxy-3-phenylpropanesulfonimidomorpholide

Base Information

• Chemical Name: N-(p-tolyl)-3-hydroxy-3-phenylpropanesulfonimidomorpholide
• CAS No.: 157734-20-8
• Molecular Formula: C₂₀H₂₆N₂O₃S
• Molecular Weight: 374.504
• Mol file: 157734-20-8.mol

Synonyms:N-(p-tolyl)-3-hydroxy-3-phenylpropanesulfonimidomorpholide

Chemical Property of N-(p-tolyl)-3-hydroxy-3-phenylpropanesulfonimidomorpholide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-(p-tolyl)-3-hydroxy-3-phenylpropanesulfonimidomorpholide

There total 1 articles about N-(p-tolyl)-3-hydroxy-3-phenylpropanesulfonimidomorpholide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

styrene oxide (96-09-3) + N-(p-tolyl)methanesulfonimidomorpholide (76867-83-9) → N-(p-tolyl)-3-hydroxy-3-phenylpropanesulfonimidomorpholide (157734-20-8)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) ether, hexane, RT, 30 min, 2.) ether, hexane, 12 h;

DOI:10.1246/bcsj.67.1855

Reference yield: 91.0%

tert-butyldimethylsilyl chloride (18162-48-6) + N-(p-tolyl)-3-hydroxy-3-phenylpropanesulfonimidomorpholide (157734-20-8) → C26H40N2O3SSi (157734-21-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 45 ℃; for 48h;

DOI:10.1246/bcsj.67.1855

Reference yield:

N-(p-tolyl)-3-hydroxy-3-phenylpropanesulfonimidomorpholide (157734-20-8) → C27H43N2O3SSi(1+)*CF3O3S(1-)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / imidazole / dimethylformamide / 48 h / 45 °C

2: CH₂Cl₂ / 72 h

With 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.67.1855

upstream raw materials:

styrene oxide

N-(p-tolyl)methanesulfonimidomorpholide

Downstream raw materials:

C₂₆H₄₀N₂O₃SSi