(1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol

Base Information

Chemical Name:(1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol
CAS No.:845536-58-5
Molecular Formula:C₄₁H₆₈O₉Si
Molecular Weight:733.071
Hs Code.:

(1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol

Synonyms:(1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol

Suppliers and Price of (1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol

There total 6 articles about (1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 845536-63-2
(1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-1-triethylsilyloxy-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-ene

: 845536-58-5
(1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1021/ol047779s

Reference yield:

: 845536-46-1
(2S,3R,2'S,3'S,5'S)-3-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2-methyl-3-triethylsilanyloxypropan-1-ol

: 845536-58-5
(1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrapropylammonium peruthenate; 4-methylmorpholine-N-oxide / CH₂Cl₂ / 0.67 h / 20 °C

2.1: (-)-B-methoxydiisopinocampheylborane; n-BuLi; tert-BuOK / BF₃*Et₂O / tetrahydrofuran; diethyl ether / 1 h / -78 - -45 °C

2.2: tetrahydrofuran / 4 h / -78 °C

2.3: 18.8 mg / NaOH; H₂O₂ / H₂O / 12 h / 20 °C

3.1: 95 percent / tetrabutylammonium iodide; 2,6-lutidine; DMAP / CH₂Cl₂ / 3 h / Heating

4.1: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With (-)-B-methoxydiisopinocamphenylborane; 2,6-dimethylpyridine; dmap; n-butyllithium; tetrapropylammonium perruthennate; potassium tert-butylate; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; 4-methylmorpholine N-oxide; boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane; 2.2: Brown asymmetric crotylation;
DOI:10.1021/ol047779s

Reference yield:

: 845536-62-1
(2S,3R,2'S,3'S,5'S)-3-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2-methyl-3-triethylsilanyloxypropanal

: 845536-58-5
(1R,2R,3S,4S,2'S,3'S,5'S)-1-[2-(6'-benzyloxy-2'-methoxymethoxy-3',5'-dimethylhexyl)-3,5,6-trimethoxy-4-methylphenyl]-2,4-dimethyl-3-(2-trimethylsilanylethoxymethoxy)hex-5-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: (-)-B-methoxydiisopinocampheylborane; n-BuLi; tert-BuOK / BF₃*Et₂O / tetrahydrofuran; diethyl ether / 1 h / -78 - -45 °C

1.2: tetrahydrofuran / 4 h / -78 °C

1.3: 18.8 mg / NaOH; H₂O₂ / H₂O / 12 h / 20 °C

2.1: 95 percent / tetrabutylammonium iodide; 2,6-lutidine; DMAP / CH₂Cl₂ / 3 h / Heating

3.1: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With (-)-B-methoxydiisopinocamphenylborane; 2,6-dimethylpyridine; dmap; n-butyllithium; potassium tert-butylate; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane; 1.2: Brown asymmetric crotylation;
DOI:10.1021/ol047779s