(2R,4R,6S)-2,4,6-Trimethyl-7-phenyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Base Information

Chemical Name:(2R,4R,6S)-2,4,6-Trimethyl-7-phenyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide
CAS No.:191927-40-9
Molecular Formula:C₂₆H₃₇NO₂
Molecular Weight:395.585
Hs Code.:

Synonyms:(2R,4R,6S)-2,4,6-Trimethyl-7-phenyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

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Chemical Property of (2R,4R,6S)-2,4,6-Trimethyl-7-phenyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

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Technology Process of (2R,4R,6S)-2,4,6-Trimethyl-7-phenyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

There total 8 articles about (2R,4R,6S)-2,4,6-Trimethyl-7-phenyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 191927-38-5
((2S,4R)-5-Iodo-2,4-dimethyl-pentyl)-benzene

: 191927-40-9
(2R,4R,6S)-2,4,6-Trimethyl-7-phenyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at 23 ℃; for 18h;
DOI:10.1055/s-1997-6121

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 191927-40-9
(2R,4R,6S)-2,4,6-Trimethyl-7-phenyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 0.5 h / 23 °C

2: 93 percent / LiCl, diisopropylamine, n-BuLi / tetrahydrofuran / 18 h / 23 °C

With n-butyllithium; triethylamine; diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja970402f

Reference yield:

: 77943-96-5
(2R)-2-methyl-3-phenyl-1-propanol

: 191927-40-9
(2R,4R,6S)-2,4,6-Trimethyl-7-phenyl-heptanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / PPh₃, I₂, imidazole

2: 1) LDA, LiCl, 2) LDA, H₃N*BH₃ / 1) THF, 23 deg C, 2) 23 deg C

3: 96 percent / PPh₃, I₂, imidazole

4: 93 percent / LDA, LiCl / tetrahydrofuran / 18 h / 23 °C

With 1H-imidazole; borane-ammonia complex; iodine; triphenylphosphine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1055/s-1997-6121