(2R)-2-methyl-3-phenyl-1-propanol

Base Information

• Chemical Name: (2R)-2-methyl-3-phenyl-1-propanol
• CAS No.: 77943-96-5
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 150.221
• Mol file: 77943-96-5.mol

Synonyms:(2R)-2-methyl-3-phenyl-1-propanol

Chemical Property of (2R)-2-methyl-3-phenyl-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-methyl-3-phenyl-1-propanol

There total 301 articles about (2R)-2-methyl-3-phenyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + 3-Phenyl-1-propanol (122-97-4) → 2-methyl-3-phenylpropanol (22436-06-2,77943-96-5,78964-61-1,7384-80-7)

Guidance literature:

With potassium hydroxide; In water; for 16h; Autoclave; Heating;

DOI:10.1002/cssc.201701607

Reference yield: 90.0%

(2'S,4R,5S)-3-(2'-methyl-3'-phenylpropionyl)-4-methyl-5-phenyloxazolidin-2-one (80697-94-5) → 4-methyl-5-phenyloxazolidin-2-one (77943-39-6) + (S)-2-methyl-3-phenylpropan-1-ol (7384-80-7,77943-96-5,78964-61-1,22436-06-2)

Guidance literature:

With Cp*RuCl{(C6H5)2P-(CH2)2NH2-κ2-P,N}; potassium tert-butylate; hydrogen; In isopropyl alcohol; at 80 ℃; for 20h; under 22502.3 Torr; optical yield given as %ee; Autoclave;

DOI:10.1002/anie.200805307

Reference yield: 60.0%

allylbenzene (300-57-2,57807-91-7) + formic acid (64-18-6) → 4-phenyl-butan-1-ol (3360-41-6) + 2-methyl-3-phenylpropanol (22436-06-2,77943-96-5,78964-61-1,7384-80-7)

Guidance literature:

With dodecacarbonyl-triangulo-triruthenium; sodium formate; lithium chloride; at 150 ℃; for 24h; Autoclave; Ionic liquid;

DOI:10.1002/adsc.201200748

upstream raw materials:

(2S)-2-methyl-3-phenylpropanal

2-methyl-3-phenylpropionic acid

benzyl bromide

(2'R,3'R,5R)-(-)-1-(3'-hydroxy-2'-methyl-3'-phenyl-1'-oxopropyl)-3,3,5-trimethyl-2-pyrrolidinone

Downstream raw materials:

C₂₀H₂₁F₃O₃

(2S)-2-methyl-3-phenylpropyl acetate

(R)-2-methyl-3-phenyl-1-propyl acetate

2-Hydroxy-5-nitro-benzoic acid 2-methyl-3-phenyl-propyl ester

Refernces

• 1、 Ferraboschi, Patrizia,Casati, Silvana,Santaniello, Enzo. "BAKER'S YEAST-MEDIATED HYDROGENATION OF 2-SUBSTITUTED ALLYL ALCOHOLS: A BIOCATALYTIC ROUTE TO A NEW HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (R)-2-METHYL ALKANOLS". . p. 19 - 20. Retrieved 1994.
• 2、 Cutolo, Giuliano,Pratt, Matthew R.,Shankar, Sahiti N.. "Your mother was right, washing matters: An alkyne-analog of ibuprofen reveals unwanted reactivity of aromatic compounds with proteins during copper-catalyzed click chemistry". supporting information. . Retrieved 2021/07/19.
• 3、 Ruiz-Casta?eda, Margarita,Santos, Lucía,Manzano, Blanca R.,Espino, Gustavo,Jalón, Félix A.. "A Water/Toluene Biphasic Medium Improves Yields and Deuterium Incorporation into Alcohols in the Transfer Hydrogenation of Aldehydes". . p. 1358 - 1372. Retrieved 2021/03/16.