3-((3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Base Information

Chemical Name:3-((3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid
CAS No.:1445878-93-2
Molecular Formula:C₃₁H₃₅N₅O₇S
Molecular Weight:621.714
Hs Code.:

Synonyms:3-((3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Chemical Property of 3-((3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Technology Process of 3-((3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

There total 9 articles about 3-((3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1445880-12-5
methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

: 1445878-93-2
3-((3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; at 20 ℃; for 20h;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445878-93-2
3-((3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 0.5 h / 0 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

5: acetic acid / 1 h / 50 °C

6: lithium hydroxide; water / methanol / 20 h / 20 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; acetic acid; triethylamine; lithium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1445879-81-1
7-bromo-4-hydroxy-3-quinolinesulfonyl chloride

: 1445878-93-2
3-((3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 3 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

4: acetic acid / 1 h / 50 °C

5: lithium hydroxide; water / methanol / 20 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; acetic acid; triethylamine; lithium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane; water;