methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

Base Information

Chemical Name:methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate
CAS No.:1445880-12-5
Molecular Formula:C₃₂H₃₇N₅O₇S
Molecular Weight:635.741
Hs Code.:

Synonyms:methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

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Chemical Property of methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

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Technology Process of methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

There total 7 articles about methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: methyl 3-amino-5-isopropoxybenzoate

: 1445880-11-4
4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

: 1445880-12-5
methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

Guidance literature:: With acetic acid; at 50 ℃; for 1h;

Reference yield:

: 1445879-81-1
7-bromo-4-hydroxy-3-quinolinesulfonyl chloride

: 1445880-12-5
methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

4: acetic acid / 1 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1445879-94-6
7-bromo-4-chloro-N-cyclohexyl-3-quinolinesulfonamide

: 1445880-12-5
methyl 3-(3-(N-cyclohexylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

2: acetic acid / 1 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; In 1,4-dioxane; water;