4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Base Information

Chemical Name:4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide
CAS No.:1445880-11-4
Molecular Formula:C₂₁H₂₃ClN₄O₄S
Molecular Weight:462.957
Hs Code.:

Synonyms:4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

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Chemical Property of 4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

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Technology Process of 4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

There total 5 articles about 4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1445879-94-6
7-bromo-4-chloro-N-cyclohexyl-3-quinolinesulfonamide

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445880-11-4
4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 1h; Inert atmosphere;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445880-11-4
4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 0.5 h / 0 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1445879-81-1
7-bromo-4-hydroxy-3-quinolinesulfonyl chloride

: 1445880-11-4
4-chloro-N-cyclohexyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water;